【Product Name】3-Chloro-4-fluoroaniline
【Synonyms】3-氯-4-氟苯胺
【CAS】367-21-5
【Formula】C6H5ClFN
【Molecular Weight】145.56
【EINECS】206-682-8
【Beilstein/Gmelin】1562786
【Beilstein Reference】4-12-00-01239
【EC Class】harmful
Physical ａnd Chemical Properties
【Appearance】Black to dark-purple powder.
【Solubility in water】10 g/L (20 C)
【Melting Point】41 - 44
【Boiling Point】230
【Density】1.226 g/cm3 (20 C)
【Partition Coefficient】2.12
First Aid Measures
【Ingestion】Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious ａnd alert, rinse mouth ａnd drink 2-4 cupfuls of milk or water.
【Inhalation】Remove from exposure to fresh air immediately. If breathing is difficult, give oxygen. Get medical aid. DO NOT use mouth-to-mouth respiration. If breathing has ceased apply artificial respiration using oxygen ａnd a suitable mechanical device such as a bag ａnd a mask.
【Skin】Get medical aid. Flush skin with plenty of soap ａnd water for at least 15 minutes while removing contaminated clothing ａnd shoes. Wash clothing before reuse.
【Eyes】Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper ａnd lower eyelids. Get medical aid.
Handling ａnd Storage
【Storage】Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Do not expose to air. Store under an inert atmosphere.
【Handling】Wash thoroughly after handling. Use with adequate ventilation. Minimize dust generation ａnd accumulation. Avoid contact with eyes, skin, ａnd clothing. Keep container tightly closed. Avoid ingestion ａnd inhalation. Handle under an inert atmosphere. Store protected from air.
Hazards Identification
【Inhalation】May cause respiratory tract irritation. May cause methemoglobinemia, cyanosis, convulsions, tachycardia, dyspnea, ａnd death. May cause cardiac abnormalities. Inhalation at high concentrations may cause CNS depression ａnd asphixiation.
【Skin】May cause skin irritation.
【Eyes】May cause eye irritation.
【Ingestion】May cause irritation of the digestive tract. May cause cardiac disturbances. May cause methemoglobinemia, cyanosis, convulsions, ａnd death. May cause central nervous system depression.
【Hazards】Contact with metals may evolve flammable hydrogen gas.
【EC Risk Phrase】R 23/24/25 33
【EC Safety Phrase】S 28 36/37 45
【UN (DOT)】2811
Exposure Controls/Personal Protection
【Personal Protection】Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA＇s eye ａnd face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
【Respirators】Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
【Exposure Effects】May cause methemoglobinemia, which is characterized by chocolate-brown colored blood, headache, weakness, dizziness, breath shortness, cyanosis, rapid heart rate, unconsciousness ａnd possible death.
Fire Fighting Measures
【Flash Point】114
【Fire Fighting】Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), ａnd full protective gear. During a fire, irritating ａnd highly toxic gases may be generated by thermal decomposition or combustion. Containers may explode when heated. Non-combustible, substance itself does not burn but may decompose upon heating to produce irritating, corrosive and/or toxic fumes. Runoff from fire control or dilution water may cause pollution. Extinguishing media: Use water spray to cool fire-exposed containers. For small fires, use dry chemical, carbon dioxide, or water spray. For large fires, use dry chemical, carbon dioxide, alcohol-resistant foam, or water spray.
【Fire Potential】Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes.
Accidental Release Measures
【Small spills/leaks】Vacuum or sweep up material ａnd place into a suitable disposal container. Clean up spills immediately, using the appropriate protective equipment. Avoid generating dusty conditions. Provide ventilation. Place under an inert atmosphere.
Stability ａnd Reactivity
【Disposal Code】9
【Incompatibilities】Air, acids, acid chlorides, acid anhydrides, chloroformates, oxidizing agents.
【Stability】Stable under normal temperatures ａnd pressures.
【Decomposition】Hydrogen chloride, nitrogen oxides, carbon monoxide, irritating ａnd toxic fumes ａnd gases, carbon dioxide, hydrogen fluoride.
【Combustion Products】Fire may produce irritating, corrosive and/or toxic gases.
Transport Information
【UN Number】2811
【Hazard Class】6.1
【Packing Group】I; II; III
【HS Code】2921 42 10