P28329 (Human)产品名称
Anti-Myelin Basic蛋白抗体
参阅全部 Myelin Basic Protein 一抗
描述
兔多克隆抗体to Myelin Basic蛋白
宿主
Rabbit
特异性
This antibody is specific to myelin basic proteins. It may cross react with other isoforms of myelin basic proteins.
经测试应用
适用于: Sandwich ELISAmore details
种属反应性
与反应: Pig
预测可用于: Mammals
免疫原
Full length native protein (purified) corresponding to Cow Myelin Basic Protein.

常规说明
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查找：ANTI-MYELIN BASIC PROTEIN ANTIBODY

功能
The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation ａnd stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, ａnd may also be involved in signaling pathways in T-cells ａnd neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation.
组织特异性
MBP isoforms are found in both the central ａnd the peripheral nervous system, whereas Golli-MBP isoforms are expressed in fetal thymus, spleen ａnd spinal cord, as well as in cell lines derived from the immune system.
疾病相关
Note=The reduction in the surface charge of citrullinated and/or methylated MBP could result in a weakened attachment to the myelin membrane. This mechanism could be operative in demyelinating diseases such as chronical multiple sclerosis (MS), ａnd fulminating MS (Marburg disease).
序列相似性
Belongs to the myelin basic protein family.
发展阶段
Expression begins abruptly in 14-16 week old fetuses. Even smaller isoforms seem to be produced during embryogenesis; some of these persisting in the adult. Isoform 4 expression is more evident at 16 weeks ａnd its relative proportion declines thereafter.
翻译后修饰
Several charge isomers of MBP; C1 (the most cationic, least modified, ａnd most abundant form), C2, C3, C4, C5, C6, C7, C8-A ａnd C8-B (the least cationic form); are produced as a result of optional PTM, such as phosphorylation, deamidation of glutamine or asparagine, arginine citrullination ａnd methylation. C8-A ａnd C8-B contain each two mass isoforms termed C8-A(H), C8-A(L), C8-B(H) ａnd C8-B(L), (H) standing for higher ａnd (L) for lower molecular weight. C3, C4 ａnd C5 are phosphorylated. The ratio of methylated arginine residues decreases during aging, making the protein more cationic.
The N-terminal alanine is acetylated (isoform 3, isoform 4, isoform 5 ａnd isoform 6).
Arg-241 was found to be 6% monomethylated ａnd 60% symmetrically dimethylated.

原创作者：上海笃玛生物科技有限公司