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技术文章
NLRP3 Antibody (N-term) Catalog Number：OM215439
点击次数：47 发布时间：2024/8/30 15:14:03
Product Profile
| Product Name | NLRP3 Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
Key Feature
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB~~1:100~500 IHC~~1:10~50: | |
| Species Reactivity | Human |
| Concentration | 1 mg/ml |
| Purification |
Target Information
| Gene Synonyms | More |
|---|---|
| Alternative Names | More |
| Molecular Weight(MW) | 118173 Da |
| Function | May function as an inducer of apoptosis. Interacts selectively with ASC ａnd this complex may function as an upstream activator of NF-kappa-B signaling. Inhibits TNF-alpha induced activation ａnd nuclear translocation of RELA/NF-KB p65. Also inhibits transcriptional activity of RELA. Activates caspase-1 in response to a number of triggers including bacterial or viral infection which leads to processing ａnd release of IL1B ａnd IL18 More |
| Tissue Specificity | Expressed in blood leukocytes. Strongly expressed in polymorphonuclear cells ａnd osteoblasts. Undetectable or expressed at a lower magnitude in B- ａnd T-lymphoblasts, respectively. High level of expression detected in chondrocytes Detected in non-keratinizing epithelia of oropharynx, esophagus ａnd ectocervix ａnd in the urothelial layer of the bladder |
| Cellular Localization | Cylasm. |
Database Links
| Entrez Gene | 114548 |
|---|
Application
-
Application
Western blot analysis of NLRP3 Antibody (N-term) in MDA-MB231 cell line lysates (35ug/lane).NLRP3 (arrow) was detected using the purified Pab.
-
Application
NLRP3 Antibody (N-term) immunohistochemistry analysis in formalin fixed ａnd paraffin embedded human lymph tissue followed by peroxidase conjugation of the secondary antibody ａnd DAB staining. This data demonstrates the use of the NLRP3 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
| Application Notes | WB~~1:100~500 IHC~~1:10~50: |
|---|
Additional Information
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot ａnd store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
原创作者：上海笃玛生物科技有限公司
