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技术文章
Rabbit anti-Pkn2 Antibody - C-terminal region Catalog Number：OM118985
点击次数：27 发布时间：2024/9/19 11:36:22
Product Profile
| Product Name | Rabbit anti-Pkn2 Antibody - C-terminal region |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | The immunogen for Anti-Pkn2 antibody is: synthetic peptide directed towards the C-terminal region of Mouse Pkn2 |
Key Feature
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. | |
| Species Reactivity | MouseHuman |
| Concentration | 1 mg/ml |
| Purification | Affinity purified |
Target Information
| Gene Symbol | Pkn2 |
|---|---|
| Gene Synonyms | More |
| Gene Full Name | protein kinase N2 |
| Gene Summary | Pkn2 is a PKC-related serine/threonine-protein kinase ａnd Rho/Rac effector protein that participates in specific signal transduction responses in the cell. It plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion ａnd transcription activation signaling processes. Pkn2 phosphorylates CTTN in hyaluronan-induced astrocytes ａnd hence decreases CTTN ability to associate with filamentous actin, phosphorylates HDAC5, therefore lead to impair HDAC5 import. It is a direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells ａnd is required for G2/M phases of the cell cycle progression ａnd abscission during cytokinesis in a ECT2-dependent manner. It stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation, regulates epithelial bladder cells speed ａnd direction of movement during cell migration ａnd tumor cell invasion, inhibits Akt pro-survival-induced kinase activity. It mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF). More |
| Alternative Names | More |
| Molecular Weight(MW) | 111kDa |
| Sequence | 983 amino acids |
Database Links
| Entrez Gene | 109333 |
|---|---|
| SwissProt ID | Q8BWW9 |
| Protein Accession | NP_848769 |
Application
-
Western blot
Host: Rabbit
Target Name: Pkn2
Sample Tissue: Mouse Thymus lysates
Antibody Dilution: 1.0ug/ml
| Application Notes | WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|---|
Additional Information
| Form | Liquid |
|---|---|
| Storage Instructions | Aliquot ａnd store at -20°C. Avoid repeated freeze / thaw cycles |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide ａnd 50% glycerol. |
原创作者：上海笃玛生物科技有限公司
