Mouse monoclonal antibody [22] to Myelin basic proteinThe protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes ａnd Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow ａnd the immune system. These mRNAs arise from the long MBP gene (otherwise called "Golli-MBP") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli ａnd the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts ａnd gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons ａnd produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit ａnd that this arra
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Human myelin basic protein

IHCIHC-FIHC-P

Human