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技术文章
MCM2 Antibody (C-term) Catalog Number：OM213423
点击次数：50 发布时间：2024/9/27 14:41:31
Product Profile
| Product Name | MCM2 Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
Key Feature
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB~~1:100~500 IHC~~1:50~100: | |
| Species Reactivity | Human |
| Concentration | 1 mg/ml |
| Purification |
Target Information
| Gene Synonyms | More |
|---|---|
| Alternative Names | More |
| Molecular Weight(MW) | 101896 Da |
| Function | Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for ＇once per cell cycle＇ DNA replication initiation ａnd elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for the entry in S phase ａnd for cell division More |
| Tissue Specificity | This MCM2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 656~685 amino acids from the C-terminal region of human MCM2. |
| Cellular Localization | Nucleus. |
Database Links
| Entrez Gene | 4171 |
|---|
Application
-
Application
Western blot analysis of MCM2 Antibody (C-term) in HL-60 cell line lysates (35ug/lane). MCM2 (arrow) was detected using the purified Pab.
-
Application
MCM2 Antibody (C-term) immunohistochemistry analysis in formalin fixed ａnd paraffin embedded human colon carcinoma followed by peroxidase conjugation of the secondary antibody ａnd DAB staining. This data demonstrates the use of the MCM2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
| Application Notes | WB~~1:100~500 IHC~~1:50~100: |
|---|
Additional Information
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot ａnd store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
原创作者：上海笃玛生物科技有限公司
