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法国HYPHEN BioMed公司（简称HBM）－－欧洲知名血液产品生产商,通过ISO9001和ISO13485双项认证,生产的大部分产品均通过欧洲CE认证,为临床诊断提供了可靠的保证.
法国HYPHEN BioMed公司是一家生产血栓止血，凝血纤溶和自身免疫的诊断试剂厂家。其产品包括：血凝试剂，发色底物，ELISA试剂盒，人和动物的纯化酶及纯化蛋白，单克隆和多克隆抗体.应用手工或者自动化的方法，为您的实验室诊断、免疫学研究，提供一系列完整的成套试剂，并广泛应用于生物技术和医产业。不断地创新，优质的服务和引进的质量标准，是法国HYPHEN BioMed对您的承诺。
发色底物法检测原理：
首先人工合成可以被待测凝血活酶催化裂解的化合物，且化合物连接上产色物质，在检测过程中产色物质可被解离下来，使被检样品中出现颜色变化，根据颜色变化可推算出被检凝血活酶的活性。产色物质一般选用连接对硝基胺（PNA）。游离的PNA呈黄色，其测定波长选用405nm。在这一波长下，其它物质对光的吸收小于PNA对光吸收的1％。具体检测方法即可采用动态法、也可采用终点法。动态法即是连续记录样品的吸光度变化，算出单位时间吸光度的变化量，并以每分钟吸光度的变化来报告结果。终点法即是指在活性酶同产色物质作用一段时间后，加入乙酸终止反应，检测此段时间内吸光度的变化，进而推算出待检酶的活性。凝血仪上多数采用动态法，因为它比终点法简单、结果更为准确。其优点主要表现在：
用酶学方法直接定量、测定结果准确、重复性好、便于自动化和标准化、所需样品量小。
凝血仪使用产色物质在检测血栓／止血指标时大致可分成三种模式。
①对酶的检测：
即在含酶的样品中直接加入产色物质，因为酶可裂解产色物质释放PNA，监测由于PNA释放而导致被检样品在405nm处光吸收的变化，就可推算样品中酶的活性。如对凝血酶、纤溶酶等的检测。
②对酶原的检测：
要对某种酶原进行测定，必须先用激活剂将其激活，使其活化位点暴露，才可将产色物质上的PNA裂解下来。加入的激活剂必须过量，因为只有这样才能使酶原被全部激活，酶原的量才会同样品中酶的活性成一定的数量关系。样品中酶的活性可通过PNA释放，即样品吸光度的变化反应出来，由此则可推算出样品中酶原的含量。
③对酶抑制物的检测：
首先往待检样品中加入过量对应的酶中和该抑制物，剩余的酶可裂解产色物质释放PNA，监测由于PNA释放而导致光吸收的变化，就可测出酶的活性，进而可推算出样品中抑制物的含量。如对抗凝血酶Ⅲ（AT-Ⅲ）等。
| 221011 | Biophen Heparin (LRT) | 4 x7.5 mL | IVD | |
| 221013 | Biophen Heparin (LRT) | 3x3 mL | IVD | |
| 221020 | BIOPHEN Heparin Anti-IIa (kinetics) | Kit | ||
| 221025 | BIOPHEN HEPARIN Anti-IIa (2 stages) | Kit | ||
| 221030 | BIOPHEN DiXaI (Direct Xa Inhibitors) | Kit | IVD | |
| 221102 | BIOPHEN Antithrombin 2.5 | 2x2.5 mL | IVD | |
| 221105 | BIOPHEN Antithrombin 5 | 4x5 mL | IVD | |
| 221122 | BIOPHEN AT (Anti-IIa) | 2x2.5 mL | IVD | |
| 221123 | BIOPHEN® AT anti-(h)-Xa LRT | 2x3x3 mL | ||
| 221127 | BIOPHEN® AT anti-(h)-Xa LRT | 2x4x7.5 mL | ||
| 221205 | BIOPHEN Protein C 5 | 4x5 mL | IVD | |
| 221211 | BIOPHEN Protein C (LRT) | 3x3 mL | IVD | |
| 221304 | BIOPHEN FVII | Kit | ||
| 221402 | BIOPHEN FVIII :C | 2x2.5 mL | IVD | |
| 221406 | BIOPHEN FVIII:C (6) | 2x6 mL | IVD | |
| 221511 | BIOPHEN Plasminogen (LRT) | 3x3 mL | IVD | |
| 221705 | BIOPHEN Factor X | 4x2.5 mL | ||
| 221802 | BIOPHEN Factor IX | 4x2.5 mL | IVD | |
| 221806 | BIOPHEN Factor IX (6) | 2x6 mL | IVD | |
| 221812 | BIOPHEN FIXa (ACT. FIX) | 2x2.5 mL | ||
| 222001 | BIOPHEN Heparin Calibrator | 5x4x1 mL | IVD | |
| 222101 | BIOPHEN Plasma Calibrator | 12x1 mL | IVD | |
| 222201 | BIOPHEN Orgaran® Calibrator | 5x4x1 mL | IVD | |
| 222301 | BIOPHEN UFH Calibrator | 5x4x1 mL | IVD | |
| 222401 | BIOPHEN V-L CAL (undiluted) | 3x3x0.5mL | IVD | |
| 222501 | BIOPHEN Arixtra® Calibrator | 4x3x1 mL | IVD | |
| 222701 | BIOPHEN Rivaroxaban® Plasma Calibrator | 3x4x1 mL | IVD | |
| 222801 | DABIGATRAN PLASMA CALIBRATOR | 3x4x1 mL | IVD | |
| 222901 | BIOPHEN® DABIGATRAN CALIBRATOR LOW | 3x4x1 mL | IVD | |
| 223001 | BIOPHEN LMWH Control Plasma | 2x6x1 mL | IVD | |
| 223101 | BIOPHEN UFH Control Plasma | 2x6x1 mL | IVD | |
| 223201 | BIOPHEN Normal Control Plasma | 12x1 mL | IVD | |
| 223301 | BIOPHEN Abnormal Control Plasma | 12x1 mL | IVD | |
| 223405 | BIOPHEN Act. PC-r Control Plasma | 12x0.5 mL | IVD | |
| 223501 | BIOPHEN Orgaran® Control - CE | 2x6x1 mL | IVD | |
| 223602 | BIOPHEN Normalplasma 2 | 10x2 mL | IVD | |
| 223605 | BIOPHEN Normalplasma 5 | 8x5 mL | IVD | |
| 223701 | BIOPHEN LMWH Control Low | 2x6x1 mL | IVD | |
| 223801 | BIOPHEN LMWH Control C3 | 12x1 mL | IVD | |
| 223901 | BIOPHEN UFH Control C2 | 12x1 mL | IVD | |
| 224001 | BIOPHEN Arixtra® Control Plasma | 2x6x1 mL | IVD | |
| 224101 | BIOPHEN UFH Control C1 | 12x1 mL | IVD | |
| 224201 | BIOPHEN LMWH Control C4 | 12x1 mL | IVD | |
| 224301 | BIOPHEN LMWH Control Low CI | 12x1 mL | IVD | |
| 224401 | BIOPHEN LMWH Control Low CII | 12x1 mL | IVD | |
| 224501 | BIOPHEN Rivaroxaban® Control Plasma | 2x6x1 mL | IVD | |
| 224601 | BIOPHEN FIXa Control set | 2x6x1 mL | ||
| 224701 | Dabigatran Control Plasma | 2x6x1 mL | IVD | |
| 224801 | BIOPHEN FXIa control set | 2x3x1 mL | ||
| 225001 | BIOPHEN® DABIGATRAN CONTROL LOW | 2x6x1 mL | IVD | |
| 225101 | BIOPHEN Rivaroxaban Control Low | 2x6x1 mL | IVD | |
| 225201 | BIOPHEN Apixaban Control Low | 2x6x1 mL | IVD | |
| 225301 | BIOPHEN Apixaban Control | 2x6x1 mL | IVD | |
| 226001 | BIOPHEN Rivaroxaban Calibrator Low | 3x4x1 mL | IVD | |
| 226101 | BIOPHEN Apixaban Calibrator Low | 3x4x1 mL | IVD | |
| 226201 | BIOPHEN Apixaban Calibrator | 3x4x1 mL | IVD | |
| 229001 | BIOPHEN CS-01(38) - Thrombin Chromogenic substrate | 1 x 25 mg | ||
| 229005 | BIOPHEN CS-01(81) - Thrombin Chromogenic Substrate | 1 x 25 mg | ||
| 229011 | Biophen CS-11(32) - Factor Xa Chromogenic Substrate | 1 x 25 mg | ||
| 229014 | Biophen CS-11(65) - Factor Xa Chromogenic Substrate | 1 x 25 mg | ||
| 229015 | Biophen CS-11(22) - Factor Xa Chromogenic substrate | 1 x 25 mg | ||
| 229021 | Biophen CS-21(66) - Activated Protein C Chromogenic substrate | 1 x 25 mg | ||
| 229031 | Biophen CS-31(02) - Kallicrein Chromogenic substrate | 1 x 25 mg | ||
| 229041 | Biophen CS-41(03) - Plasmin ａnd Plasminogen-SK Chromogenic substrate | 1 x 25 mg | ||
| 229051 | Biophen CS-51(09) - Factor IXa Chromogenic substrate | 1 x 25 mg | ||
| 229061 | BIOPHEN CS-61 (44) - Urokinsa Chrom Substrate | 1 x 25 mg | ||
| 229091 | Biophen CS-05(88) - tPA ａnd broad spectrum Chromogenic substrate | 1 x 25 mg | ||
| 521096 | ZYMUPHEN MP-ACTIVITY | Kit of 96 tests | ||
| 521196 | ZYMUPHEN MP-TF | Kit of 2 x 48 tests | ||
| 521296 | ZYMUPHEN tPA ACTIVITY | Kit of 96 tests | ||
| 229001C | BIOPHEN CS-01(38)®Thrombin Chromogenic substrate | 12x25 mg | ||
| 229014C | Biophen CS-11(65) - Factor Xa Chromogenic substrate | 12x25 mg | ||
| AG001K | ADP | 3x 0.5 mL | IVD | |
| AG002K | Epinephrine | 3x 0.5 mL | IVD | |
| AG003K | Arachidonic Acid | 3x 0.5 mL | IVD | |
| AG004K | Ristocetin | 3x 0.5 mL | IVD | |
| AG005K | Collagen | 3x 0.5 mL | IVD | |
| AG006A | Lyophilized platelets | 1X5ml | IVD | |
| AG006K | Lyophilized platelets | 3x 5 ml | IVD | |
| AR001A | Calcium chloride 0.025M (M/40) | 3 x 25 mL | IVD | |
| AR001K | Calcium chloride 0.025M (M/40) | 12 x 25 mL | IVD | |
| AR002A | Calcium chloride 0.25M (M/4) | 1 x 25 mL | IVD | |
| AR002K | Calcium chloride 0.25M (M/4) | 3 x 25 mL | IVD | |
| AR004A | Tris-NaCl buffer | 1 x 50 mL | ||
| AR004K | Tris-NaCl buffer | 3 x 50 mL | ||
| AR005A | Tris-NaCl buffer, with Albumin - pH 7.40 | 1 x 50 mL | ||
| AR005K | Tris-NaCl buffer, with Albumin - pH 7.40 | 3 x 50 mL | ||
| AR006A | Phosphate NaCl (PBS) buffer | 1 x 50 mL | ||
| AR006K | Phosphate NaCl (PBS) buffer | 3 x 50 mL | ||
| AR007A | Phosphate NaCl (PBSA) buffer | 1 x 50 mL | ||
| AR007K | Phosphate NaCl (PBSA) buffer | 3 x 50 mL | ||
| AR008A | Tris buffer | 1 x 50 mL | ||
| AR008K | Tris buffer | 3 x 50 mL | ||
| AR009A | Tris-NaCl buffer | 1 x 50 mL | ||
| AR009K | Tris-NaCl buffer | 3 x 50 mL | ||
| AR010A | ELISA dilution buffer, with albumin | 1 x 50 mL | ||
| AR011A | Wash solution for ELISA | 1 x 50 mL | ||
| AR011K | Wash solution for ELISA | 3 x 50 mL | ||
| AR012A | Tetramethylbenzidine (TMB) substrate | 1 x 25 mL | ||
| AR013A | FPA anticoagulant solution | 1 x 20 mL | ||
| AR014A | Para-Nitro-Aniline (pNA) | 1 x 5 mL | ||
| AR015A | Tris NaCI EDTA PEG buffer | 1 x 10 mL | ||
| AR015B | Tris EDTA buffer (10x conc.) - pH 8.4 | 1 x 20 mL | ||
| AR016A | Fibrinolysis Sample Diluent (For ELISA kit) | 1 x 50 mL | ||
| AR017A | ELISA Conjugate Diluent buffer, with albumin | 1 x 25 mL | ||
| AR018A | Autoimmunity Sample Diluent (for ELISA kit) | 1 x 50 mL | ||
| AR019A | Stop solution for ELISA | 1 x 6 mL | ||
| AR020A | Tris-BSA buffer (10x conc.) - pH 7.30 | 1 x 20 mL | ||
| AR021A | Imidazole buffer | 1 x 25 mL | IVD | |
| AR021K | Imidazole buffer | 3 x 25 mL | IVD | |
| AR021L | Imidazole buffer | 12 x 25 mL | IVD | |
| AR022A | Prothrombin Activator Diluent | 1 x 20 mL | ||
| AR023A | B2F Sample Diluent | 1 x 60 mL | ||
| AR024A | Bentonite suspension | 1 x 50 mL | ||
| AR025A | Wash solution for microparticle kits | 1 x 50 mL | ||
| AR026A | Special Tris-BSA buffer | 3 x 25 mL | IVD | |
| AR026K | Special Tris-BSA buffer | 12 x 25 mL | IVD | |
| AR027A | High Sensitivity Tetramenthybenzidine substrate (TMB-HS) | 1 x 25 mL | ||
| AR103A | AT-Tris buffer-Anti Xa (Progressive Antithrombin) | 1 x 10 mL | ||
| AR104A | AT-Tris Buffer anti-IIa (Progressive Antithrombin) | 1 x 10 mL | ||
| AR105A | Sample diluent for MVV/CAEV kit | 1 x 250 mL | ||
| BE101B | Purified bovine Factor Xa | 1 x 0.5 mg | ||
| BE101C | Purified bovine Factor Xa | 1 x 15 μg | ||
| BE101D | Purified bovine Factor Xa | 1 x 30 μg | ||
| BE101K | Purified bovine Factor Xa | 6 x 50 μg | ||
| BE101L | Purified bovine Factor Xa | 10 x 30 μg | ||
| BE101O | Purified bovine Factor Xa | 1 x 50 μg | ||
| BE102A | Bovine Thrombin | 1 x 21 NIH | ||
| BE102B | Bovine Thrombin | 1 x 100 NIH | ||
| BE102C | Bovine Thrombin | 1 x 1000 NIH | ||
| BE102K | Bovine Thrombin | 6 x 21 NIH | ||
| BE501C | Bovine Thrombin | 1 x 500 NIH | ||
| BE501K | Bovine Thrombin | 10 x 500 NIH | ||
| BP101A | Purified bovine Fibrinogen | 1 x 100 mg | ||
| BP101B | Purified bovine Fibrinogen | 1 x 1 g | ||
| BP101K | Purified bovine Fibrinogen | 6 x 10 mg | ||
| BP101O | Purified bovine Fibrinogen | 1 x 10 mg | ||
| BP102A | Purified bovine Factor X | 1 x 100 μg | ||
| BP102K | Purified bovine Factor X | 6 x 100 μg | ||
| BP103A | Bovine Prothrombin | 1 x 1 mg | ||
| BP103K | Bovine Prothrombin | 6 x 1 mg | ||
| BP104C | Bovine anti-Thrombin (AT) | 1 x 10 mg | ||
| BP105C | Bovine Plasminogen | 1 x 5 mg | ||
| CK001K | HEMOCLOT Thrombin (human) | 6 x 2 mL | ||
| CK001L | HEMOCLOT Thrombin (human) | 6 x 8 mL | ||
| CK002K | HEMOCLOT Thrombin Inhibitors | 3x1 mL | IVD | |
| CK002L | HEMOCLOT Thrombin Inhibitors | 3x2.5 mL | IVD | |
| CK011K | HEMOCLOT Thrombin Time (T. | 6 x 2 mL | IVD | |
| CK011L | HEMOCLOT Thrombin Time (T. | 6 x 8 mL | IVD | |
| CK031K | HEMOCLOT Protein C | 3x1 mL | IVD | |
| CK041K | HEMOCLOT Protein S | 3x1 mL | IVD | |
| CK051K | HEMOCLOT VII-X | 6 x 1 mL | IVD | |
| CK051L | HEMOCLOT VII-X | 20 x 1 mL | IVD | |
| CK065K | HEMOCLOT Quanti. V-L | Kit | IVD | |
| CK071K | HEMOCLOT Factor V Reagent | 6 x 1 mL | IVD | |
| CK081K | HEMOCLOT FVII Reagent | 6 x 1 mL | IVD | |
| CK511K | CEPHEN 1 | 6 x 1mL | IVD | |
| CK512K | CEPHEN 2.5 | 6 x 2.5 mL | IVD | |
| CK515K | CEPHEN 5 | 8 x 5 mL | IVD | |
| CK515L | CEPHEN 5 | 12 x 5 mL | IVD | |
| CK521K | CEPHEN 1 LS | 6 x 1mL | IVD | |
| CK522K | CEPHEN 2.5 LS | 6 x 2.5mL | IVD | |
| CK571K | FIBRIPHEN 1 | 6 x 1mL | IVD | |
| CK572K | FIBRIPHEN 2 | 6 x 2mL | IVD | |
| CK575K | FIBRIPHEN 5 | 8 x 5mL | IVD | |
| DP010A | Prothrombin Deficient Plasma | 1 x 1 mL | IVD | |
| DP010K | Prothrombin Deficient Plasma | 6 x 1 mL | IVD | |
| DP020A | Factor V Deficient Plasma | 1 x 1 mL | IVD | |
| DP020K | Factor V Deficient Plasma | 6 x 1 mL | IVD | |
| DP030A | Factor VII Deficient Plasma | 1 x 1 mL | IVD | |
| DP030K | Factor VII Deficient Plasma | 6 x 1 mL | IVD | |
| DP040A | FVIII:C Deficient Plasma | 1 x 1 mL | IVD | |
| DP040K | FVIII:C Deficient Plasma | 6 x 1 mL | IVD |
